The Key Role of Mitochondria in Somatic Stem Cell Differentiation: From Mitochondrial Asymmetric Apportioning to Cell Fate

The study of the mechanisms underlying stem cell differentiation is under intensive research and includes contribution a metabolic switch from glycolytic to oxidative metabolism. While mitochondrial biogenesis has been previously demonstrated in number models, it only recently that role dynamics started be explored. discovery asymmetric distribution mitochondria progeny strengthened interest field. This review attempts summarize regulation apportioning by fusion, fission, mitophagy processes as well emphasize how cells affects their metabolism, thus epigenetics, determines fate.